View abstract. View abstract. Oxid.Med.Cell Longev. A rare, inherited disorder that causes muscle pain and cramping (McArdle disease). International Society of Sports Nutrition position stand: safety and efficacy of creating supplementation in exercise, sport, and medicine. View abstract. Gastric acidity influences the blood response to a beta-carotene dose in humans. Kilduff, L. P., Georgiades, E., James, N., Minnion, R. H., Mitchell, M., Kingsmore, D., Hadjicharlambous, M., and Pitsiladis, Y. P. The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. Muscle strength. Am J Physiol Endocrinol.Metab 2005;288(2):E347-E352. 2016 May;30(5):1438-46. The effects of ergogenic compounds on myogenic satellite cells. Side Effects of Creatine In appropriate doses, creatine is generally safe to take. View abstract. Acta Physiol Scand 1995;155:387-95. Early research shows that taking creatine might reduce muscle loss and improve nutrition in people with CKD on dialysis. Magn Reson.Imaging 2010;28(5):698-707. Early research shows that taking creatine by mouth daily for 2 months does not improve symptoms or mental function in people with schizophrenia. Eckerson, J. M., Stout, J. R., Moore, G. A., Stone, N. J., Nishimura, K., and Tamura, K. Effect of two and five days of creatine loading on anaerobic working capacity in women. Early research shows that taking 5 grams of creatine four times daily for 5 days followed by 5 grams daily for 16 weeks improves strength in women with fibromyalgia. Persky AM, Muller M, Derendorf H, et al. Eur.J.Appl.Physiol 2011;111(5):749-756. McMorris, T., Mielcarz, G., Harris, R. C., Swain, J. P., and Howard, A. Creatine supplementation and cognitive performance in elderly individuals. Maganaris, C. N. and Maughan, R. J. Creatine supplementation enhances maximum voluntary isometric force and endurance capacity in resistance trained men. 2009;23(6):1663-1669. Med.Sci.Sports Exerc. This content is imported from {embed-name}. View abstract. Early research shows that taking creatine by mouth does not improve muscle function or quality of life in people with mitochondrial myopathies. View abstract. The effect of oral creatine supplementation on maximal exercise performance in competitive rowers. View abstract. USA.gov. View abstract. Walter MC, Lochmuller H, Reilich P, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Creatine isn't recommended for people with kidney or liver disease, or diabetes . Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. J Sports Sci 1996;14:175-9. eCollection 2017. J Sci Med Sport 2005;8(3):305-313. 2017 Jun;27(3):285-92. Effects of creatine supplementation on renal function. Is the use of oral creatine supplementation safe? Wiroth, J. Although creatine monohydrate appears to be a relatively safe supplement, some side effects have been reported. View abstract. Med.Sci.Sports Exerc. 2000 Mar;41(3):255-64. doi: 10.1006/phrs.1999.0618. View abstract. Golini J, Jones WL. Romer, L. M., Barrington, J. P., and Jeukendrup, A. E. Effects of oral creatine supplementation on high intensity, intermittent exercise performance in competitive squash players. Amino Acids 2012;42(6):2299-305. Kreider R, Ransom J, Rasmussen C, and et al. Medicine & Science in Sports & Exercise 1996;28(5):81. Comparison of creatine supplementation before versus after supervised resistance training in healthy older adults. Kuehl K, Goldberg L, and Elliot D. Renal insufficiency after creatine supplementation in a college football athlete. 2001;33(10):1674-1681. View abstract. Francaux M, Poortmans JR. Effects of creatine monohydrate supplementation during combined strength and high intensity rowing training on performance. J Gerontol A Biol Sci Med Sci. Early research on the use of creatine by mouth in people with muscular dystrophy is not clear. Deutekom, M., Beltman, J. G., de Ruiter, C. J., de Koning, J. J., and de Haan, A. Kirksey KB, Warren BJ, Stone MH, and et al. View abstract. View abstract. Respirology. Med Sci Sports Exerc 2001;33:183-8. Depression. 1999;9(2):136-145. Watson, G., Casa, D. J., Fiala, K. A., Hile, A., Roti, M. W., Healey, J. C., Armstrong, L. E., and Maresh, C. M. Creatine use and exercise heat tolerance in dehydrated men. Rahimi, R. Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. Common creatine side effects may include: nausea, stomach pain; diarrhea; muscle cramps; or weight gain. View abstract. Sports Med 1999;28:49-60. J Neurol.Sci. Renema, W. K., Schmidt, A., van Asten, J. J., Oerlemans, F., Ullrich, K., Wieringa, B., Isbrandt, D., and Heerschap, A. MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: validation of an animal model to study creatine deficiency. Nutrition 2005;21(3):301-307. Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills? The New York Times. Nutr Res 2000;20:505-14. Recovery after surgery. So before you go all-in on taking creatine, here's what the supplement actually is, what it does, and how to avoid any of its side effects. View abstract. Early research shows that taking creatine by mouth for 5 days reduces blood sugar after eating in people with newly diagnosed diabetes. J Int Soc Sports Nutr. View abstract. Current Therapeutic Research 1991;50(5):591-298. View abstract. View abstract. 2005;15(9):1923-1926. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Arginine-glycine amidinotransferase (AGAT) deficiency is another disorder that prevents the body from making creatine. View abstract. View abstract. Creatine supplementation and sprint performance in soccer players. 2002;83(1):19-23. Eur J Appl Physiol 2014;114(8):1749-55.del Favero S, Roschel H, Artioli G, et al. J Sports Med Phys Fitness. View abstract. View abstract. Cochrane.Database.Syst.Rev 2007;(1):CD004760. View abstract. This is not a complete list of side effects and others may occur. The present review is not intended to reach conclusions on the effect of creatine supplementation on sport performance, but we believe that there is no evidence for deleterious effects in healthy individuals. Liver and kidney dysfunction have also been suggested on the basis of small changes in markers of organ function and of occasional case reports, but well controlled studies on the adverse effects of exogenous creatine supplementation are almost nonexistent. View abstract. Dehydration 7. Kim HJ, Kim CK, Carpentier A, Poortmans JR. Amino Acids. View abstract. View abstract. Candow, D. G., Little, J. P., Chilibeck, P. D., Abeysekara, S., Zello, G. A., Kazachkov, M., Cornish, S. M., and Yu, P. H. Low-dose creatine combined with protein during resistance training in older men. J.Int.Soc.Sports Nutr. 2017;14:18. A., Menon, K., Northey, D., Liu, J., Kufe, D. W., and Kaddurah-Daouk, R. Cyclocreatine in cancer chemotherapy. Int J Sport Nutr. Sports Medicine, Training and Rehabilitation. View abstract. 2003;35(11):1946-1955. Faager, G., Soderlund, K., Skold, C. M., Rundgren, S., Tollback, A., and Jakobsson, P. Creatine supplementation and physical training in patients with COPD: a double blind, placebo-controlled study. Redondo, D. R., Dowling, E. A., Graham, B. L., Almada, A. L., and Williams, M. H. The effect of oral creatine monohydrate supplementation on running velocity. View abstract. View abstract. 1997;131(4):626-631. Jones AM, Atter T, Georg KP. Heat intolerance 10. Acta Paediatr. Eur Radiol. Cooke WH, Grandjean PW, Barnes WS. J Strength.Cond.Res 2003;17(3):425-438. Acta Physiol Scand. Eur.J Appl.Physiol Occup.Physiol 1998;77(4):360-365. Chrusch, M. J., Chilibeck, P. D., Chad, K. E., Davison, K. S., and Burke, D. G. Creatine supplementation combined with resistance training in older men. Jager R, Purpura M, Shao A, et al. Certain studies suggest that side effects of creatine may include: Weight gain due to water retention (sometimes up to three to five pounds of weight gain in a … View abstract. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Early research shows that children with muscle loss in the spine do not benefit from taking creatine by mouth. de Guingand DL, Palmer KR, Snow RJ, Davies-Tuck ML, Ellery SJ. Kley, R. A., Vorgerd, M., and Tarnopolsky, M. A. Creatine for treating muscle disorders. Usually, consumers do not report any adverse effects, but body mass increases. 2018;15(1):38. J.Strength.Cond.Res. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine.